Functional Precision Medicine Successfully Guides Therapeutic Regimen of ‘Cancer of Unknown Primary’ Later Classified as Triple-Negative Breast Cancer: A Case Report
Ruhe L, Heibl S, Czompo M, Haybaeck J, Loskutov J, Regenbrecht MJ, Thaler J, Wedeken L, Regenbrecht CRA. Functional precision medicine successfully guides therapeutic regimen of ‘cancer of unknown primary’ later classified as triple-negative breast cancer: a case report. Case Rep Oncol. Case Rep Oncol (2024) 17 (1): 490–496. doi: 10.1159/000538137
Photon and Proton irradiation in Patient-derived, Three-Dimensional Soft Tissue Sarcoma Models
Roohani S, Loskutov J, Heufelder J, Ehret F, Wedeken L, Regenbrecht M, Sauer R, Zips D, Denker A, Joussen_x000D_AM, Regenbrecht CRA, Kaul D: Photon and Proton irradiation in Patient-derived, Three-Dimensional_x000D_Soft Tissue Sarcoma Models. BMC Cancer. 2023, 23(1):577.
A combined computational and functional approach identifies IGF2BP2 as a driver of chemoresistance in a wide array of pre-clinical models of colorectal cancer
Kendzia S, Franke S, Kröhler T, Golob-Schwarzl N, Schweiger C, Toeglhofer AM, Skofler C, Uranitsch S,_x000D_El-Heliebi A, Fuchs J, Punschart A, Stiegler P, Keil M, Hoffmann J, Henderson D, Lehrach H, Yaspo M, Reinhard_x000D_C, Schäfer R, Keilholz U, Regenbrecht C, Schicho R, Fickert P, Lax SF, Erdmann F, Schulz MH, Kiemer_x000D_AK, Haybaeck J, Kessler SM: […]
A RAS-Independent Biomarker Panel to Reliably Predict Response to MEK Inhibition in Colorectal Cancer
Pfohl U, Loskutov J, Bashir S, Kühn R, Herter P, Templin M, Mamlouk S, Belanov S, Linnebacher M, Bürtin_x000D_F, Vetter M, Reinhard C, Wedeken L, Regenbrecht CRA. A RAS-Independent Biomarker Panel to Reliably_x000D_Predict Response to MEK Inhibition in Colorectal Cancer. Cancers (Basel). 2022 Jul 1;14(13):3252. doi:_x000D_10.3390/cancers14133252. PMID: 35805024; PMCID: PMC9265111.
RNA sequencing of long-term label-retaining colon cancer stem cells identifies novel regulators of quiescence
Regan JL, Schumacher D, Staudte S, Steffen A, Lesche R, Toedling J, Jourdan T, Haybaeck J, Mumberg D,_x000D_Henderson D, Győrffy B, Regenbrecht CRA, Keilholz U, Schäfer R, Lange M. RNA sequencing of long-term_x000D_label-retaining colon cancer stem cells identifies novel regulators of quiescence. iScience. 2021 May_x000D_24;24(6):102618. doi: 10.1016/j.isci.2021.102618. PMID: 34142064; PMCID: PMC8185225.
Context Matters—Why We Need to Change From a One Size Fits all Approach to Made-to-Measure Therapies for Individual Patients With Pancreatic Cancer
Sankarasubramanian S, Pfohl U, Regenbrecht CRA, Reinhard C, Wedeken L. Context Matters-Why We_x000D_Need to Change From a One Size Fits all Approach to Made- to-Measure Therapies for Individual_x000D_Patients With Pancreatic Cancer. Front Cell Dev Biol. 2021 Nov 4;9:760705. doi: 10.3389/fcell.2021.760705._x000D_PMID: 34805167; PMCID: PMC8599957.
Precision Oncology Beyond Genomics: The Future Is Here—It Is Just Not Evenly Distributed
Pfohl U, Pflaume A, Regenbrecht M, Finkler S, Graf Adelmann Q, Reinhard C, Regenbrecht CRA, Wedeken_x000D_L. Precision Oncology Beyond Genomics: The Future Is Here—It Is Just Not Evenly Distributed. Cells._x000D_2021 Apr 17;10(4):928. doi: 10.3390/cells10040928. PMID: 33920536; PMCID: PMC8072767.
Peritoneal metastasis of colorectal cancer (pmCRC): identification of predictive molecular signatures by a novel preclinical platform of matching pmCRC PDX/PD3D models
Dahlmann M, Gambara G, Brzezicha B, Popp O, Pachmayr E, Wedeken L, Pflaume A, Mokritzkij M, Gül-_x000D_Klein S, Brandl A, Schweiger-Eisbacher C, Mertins P, Hoffmann J, Keilholz U, Walther W, Regenbrecht C,_x000D_Rau B, Stein U. Peritoneal metastasis of colorectal cancer (pmCRC): identification of predictive molecular_x000D_signatures by a novel preclinical platform of matching pmCRC PDX/PD3D models. […]
Heterogeneous pathway activation and drug response modelled in colorectal-tumorderived 3D cultures
Schumacher D, Andrieux G, Boehnke K, Keil M, Silvestri A, Silvestrov M, Keilholz U, Haybaeck J, Erdmann G,_x000D_Sachse C, Templin M, Hoffmann J, Boerries M, Schäfer R, Regenbrecht CRA: Heterogeneous pathway activation_x000D_and drug response modelled in colorectal-tumor-derived 3D cultures. PLoS Genet. 2019 Mar_x000D_29;15(3):e1008076. doi: 10.1371/journal.pgen.1008076. Erratum in: PLoS Genet. 2019 May 29;15(5):e1008183._x000D_PMID: 30925167; PMCID: PMC6457557.
Molecular dissection of colorectal cancer in pre-clinical models identifies biomarkers predicting sensitivity to EGFR inhibitors
Moritz Schütte, Thomas Risch, Nilofar Abdavi-Azar, Karsten Boehnke, Dirk Schumacher, Marlen Keil, Reha_x000D_Yildiriman, Christine Jandrasits, Tatiana Borodina, Vyacheslav Amstislavskiy, Catherine L. Worth, Caroline_x000D_Schweiger, Sandra Liebs, Martin Lange, Hans- Jörg Warnatz, Lee M. Butcher, James E. Barrett, Marc_x000D_Sultan, Christoph Wierling, Nicole Golob-Schwarzl, Sigurd Lax, Stefan Uranitsch, Michael Becker, Yvonne_x000D_Welte, Joseph Lewis Regan, Maxine Silvestrov, Inge Kehler, […]
